Simulating Complex Mechanochemistry of Actin Networks

Mechanochemistry of protein 4.1's spectrin-actin-binding domain: ternary complex interactions, membrane binding, network integration, structural strengthening

Mechanical strength of the red cell membrane is dependent on ternary interactions among the skeletal proteins, spectrin, actin, and protein 4.1. Protein 4.1's spectrin-actin-binding (SAB) domain is specified by an alternatively spliced exon encoding 21 amino acid (aa) and a constitutive exon encoding 59 aa. A series of truncated SAB peptides were engineered to define the sequences involved in s...

Mechanochemistry

The scientific community’s general interest in using mechanical energy to trigger or facilitate chemical reactivity has been growing at a speedy pace. In particular, in recent years, organic chemistry has witnessed a constant flow of examples where the use of mechanochemical techniques proved not only to outperform traditional solution-based methodologies, but also enabled access to otherwise i...

Cracking Elements Method for Simulating Complex Crack Growth

The cracking elements method (CEM) is a novel numerical approach for simulating fracture of quasi-brittle materials. This method is built in the framework of conventional finite element method (FEM) based on standard Galerkin approximation, which models the cracks with disconnected cracking segments. The orientation of propagating cracks is determined by local criteria and no explicit or implic...

Layered structure and complex mechanochemistry of a strong bacterial adhesive

Simulating Complex Sci Topologies

1 Simulating complex SCI topologies Geir Horn, John W. Bothner, Svein Linge, Ernst H. Kristiansen, ystein Gran Larsen Abstract| This paper shows how rather complex SCI topologies might be constructed and simulated using our present SCI simulator. We also present the serial HIC technology developed in the European OMI/HIC project. A HIC network may be used to transport SCI packets, and our new H...